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Xenobiotica covers seven main areas, including:General Xenobiochemistry, including in vitro studies concerned with the metabolism, disposition and excretion of drugs, and other xenobiotics, as well as the structure, function and regulation of associated enzymesClinical Pharmacokinetics and Metabolism, covering the pharmacokinetics and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in manAnimal Pharmacokinetics and Metabolism, covering the pharmacokinetics, and absorption, distribution, metabolism and excretion of drugs and other xenobiotics in animalsPharmacogenetics, defined as the identification and functional characterisation of polymorphic genes that encode xenobiotic metabolising enzymes and transporters that may result in altered enzymatic, cellular and clinical responses to xenobioticsMolecular Toxicology, concerning the mechanisms of toxicity and the study of toxicology of xenobiotics at the molecular levelXenobiotic Transporters, concerned with all aspects of the carrier proteins involved in the movement of xenobiotics into and out of cells, and their impact on pharmacokinetic behaviour in animals and manTopics in Xenobiochemistry, in the form of reviews and commentaries are primarily intended to be a critical analysis of the issue, wherein the author offers opinions on the relevance of data or of a particular experimental approach or methodology

外來生物學涵蓋七個主要領(lǐng)域，包括：普通外來生物化學，包括與藥物和其他外來生物的代謝、處置和排泄有關(guān)的體外研究，以及相關(guān)酶的結(jié)構(gòu)、功能和調(diào)節(jié)；臨床藥代動力學和代謝，涵蓋藥物和其他外來生物在人體內(nèi)的藥代動力學和吸收、分布、代謝和排泄；動物藥代動力學和代謝，涵蓋藥物和其他外來生物在動物內(nèi)的藥代動力學和吸收、分布、代謝和排泄；藥物遺傳學，定義為對編碼外來生物代謝酶和轉(zhuǎn)運蛋白的多態(tài)性基因的識別和功能表征，這些基因可能導致對外來生物的酶促、細胞和臨床反應(yīng)發(fā)生改變；分子毒理學，涉及外來生物的毒性機制和分子水平上的毒理學研究；外來生物轉(zhuǎn)運蛋白，涉及參與藥物運輸?shù)妮d體蛋白的所有方面。外來生物進出細胞的過程，以及它們對動物和人類藥代動力學行為的影響。以評論和評注形式出現(xiàn)的外來生物化學主題主要旨在對問題進行批判性分析，其中作者就數(shù)據(jù)的相關(guān)性或特定的實驗方法或方法論提出意見

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